뇌 세탁; 수면(睡眠)에서 찾아, 건강한 장수(長壽)로...
2014.02.22.
정 동 철
이미 <뇌 세탁기>는 나의 커다란 관심사였다.
두 가지 이유다.
첫째, 뇌에 입력된 왜곡된 기억을 생래적 유전정보에 따라 평면거울로 현실을 사실대로 직시 인지할 수 있는 길은 없을까?
둘째, 노령화시대의 생명연장을 넘어 건강한 장수로 가는 길은 어디에 있을까?
사람과 사람사이에 그래서 사실을 바탕에 둔 멋진 인생을 누리는 길
그러기 위해 뇌를 세탁할 수 있는 방법이 없겠느냐는 것이다.
<뇌 세탁기>에 이어 이곳 게시판 수필란에 소개된 <속 뇌세탁기>는 그래서 올려진 글이었다.
다행히 수면과학을 만나 그 일단의 길목을 찾아나서기에 이른다.
역시 이곳 게시판 건강칼럼에 실린, "왜 내 머리는 상쾌하지 않을까?"가 그것이다.
수면중에 뇌에 낀 찐득거리는 노폐물이 세탁되어진다는 사실 귀중한 이유다.
더 깊고 소상한 연구자료들이 필요하게 됐다.
출처-Maiken Nedergaard/Jeff Iliff
Brainwashing. When mice sleep, fluid-filled channels (pale blue) between neurons expand and flush out waste
모든 동물에게 수면은 생명유지에 필수적 기능(vital function)에 해당된다는 것은 상식이다.
잠이 보약이란 말은 우리 조상들이 즐겨 쓰던 말이다.
문제는 그 이유가 무엇인가라는 점을 역시 사실대로 밝혀내는 것이다.
수면중에 베타-아미로이드 b-amyloid가 씻겨져나간다는 사실, 즉 세탁이 된다는 것은 근래에 알려진 것이다.
의미는 매우 크다.
수면 중에 결정적 기능, 체내 대사상의 항상성 mtabolic homeostes이 뒤따르고 있기 때문이라는 것이다.
실시간 쥐에 대한 생체실험에서 tetramethylammonium과 two-photon imaging으로 확인한 결과
성상세포 astrocyte 사이의 공간들은 60%난 늘어났음을 확인할 수 있었다.
일상적 활동시의 부산물 찌꺼기들, 수면 중의 뇌척수액을 통해 대류(교환)현상이 가능해 진다는 것을 알았다.
보다 정확히 말하면 뇌를 혹사한 결과 신경독성 찌꺼기가 세탁된다는 것이다.
베타 아미로이드, 이것은 Alzhiemer's Disease 치매를 유발하는 결정적 역할인자이다.
우리가 원하는 뇌 세탁, 바로 그것이 진행된다는 것,
쥐의 생체 실험에서 수면과 마취제를 이용할 때 이같은 현상이 일어난다는 사실은
적절한 약물에 의해 역시 같은 효과를 기대할 수 있다는 점을 시사하고 있어 더욱 흥미롭다.
뇌 세탁, 이것은 바로 현실적으로 가능하다는 강력한 뜻이다.
환호, 바로 이런 것이다.
해법은 두 가지다.
하나는 양질의 수면을 어떻게 확보할 것인가?
마취제 대신 적절한 양질의 수면유도제로서 현재 사용하고 있는 것을 개발할 여지는 없는가?
A partially folded structure of amyloid-beta(1 40) in an aqueous environment (pdb 2lfm)[
Protein before and after folding.
Results of protein folding.
amyloid-beta (A4) precursor protein (peptidase nexin-II, Alzheimer disease)
출처-http://serracor.wordpress.com/
혈관 대행 경로(CFS-Cerebrospinal Fluid Circulation)를 통해 뇌 실질과 뇌 혈관 사이의 찌꺼기 화학물질
베타 아미로이드를 깨끗이 청소한다는 사실, 거듭 언급하지만 뇌 세탁이 아닐 수 없다.
동물 뇌의 성상세포들 astrocytes에 water channel aquaporin-4 (AQP4)를 제어, 늘여진 수분통로 CSF를 활성
정맥을 통해 앞에서 강조한 뇌 활동에 의해 발생되는 쓰래기 화학물 70%를 배출할 수 있다.
이것은 퇴행성 신경계에 관여한 불필요한 담백질, 녹아버린 담백질의 축적을 예방한다는 의미다.
요컨데 여기엔 Aqp4 gene 이 작용하여 중추신경계에서 베타 아미로이드를 쫓아낸다는 결론이다.
결과 나의 상상, 우리의 상상은 결국 '건강장수'
Fighting Aging 늙어감에 대한 투쟁으로 이어진다.
엄청난 연구가 필요하고 막강한 후원에 의한 연구재단이 머리를 쥐어짜고 있다.
한국, 열약한 가운데 우선 알아야 할 현실, 연구결과에 대한 자료를 통한
'창조 뇌 과학'으로 통합 정리하려는 것은 수면과 분자생물학의 이해가 주는 선물의 결과가 될 것이다.
급기야 담백질에 대한 문제가 대두되지 않을 수 없다.
수면과학은 줄기세포와 조직공학 stem cell and tissue enginering을 통한
담배질의 3D folding에 대한 관심으로 진화한다.
Protein Misfolding and Reversal of Age-Related Sleep Issues,
나이 들면 어떤 형태든 수면장애가 나타난다. 해법을 찾는 관심사다.
어리면 어릴수록 수면량이 많다. 늙어지면 그럴수록 수면량이 줄어든다.
잠을 이기지 못하는 젊은이들, 펄펄 나는 올림픽 선수들의 수면은 평소 아침이 상쾌하기에 가능하다.
늙은이들에게 기대할 수 없는, 이미 경험했던 과거는 다시 돌아오지 않는다.
대체 담백질이 잘못 접혀진다는 것, 그것은 무엇을 뜻하고 그 연유는 무엇일까?
위의 그림에서 담백질이 3D로 접힐 때 본래의 기능이 원하는 대로 이루어진다.
여기에
불완전하거나 또는 잘못 접히게 되면 결과 퇴행성 싱경을 막을 수 없다. 노년의 수면장애 역시 같은 이유다.
해당된 원문 일부를 아래에 참고적으로 남겨두는 것은 여러분의 발상에 장해가 되지 않기 위한 것이다.
아래 사진처럼 신경자기공명 Neuclear Magnetic Resonance 을 통해 얻게 되는 장비, 어마어마하다.
줄기세포 Stem Cells, 재생의학 Regenerative Medicine, 그리고 조직공학 Tissue Engineering,
이런 것 들의 연구결과와 공명현상, 결국 다시 젊어지려는 말하자면
생명공학 biotechnologies은 노인을 다시 청춘으로 rejuvenating the old 이어갈 것인가라는 문제로 간다.
Bruker 700 MHz. Nuclear Magnetic Resonance (NMR) spectrometer
과연 이기적 유전자가 이타적 유전자로 변이 아니 돌연변이를 통해 진화할 것인가?
유전자는 그것을 허락할 권한이 있어 보이진 않는다.
유전자가 인간의 의지에 따라 행보를 달리하리라는 어떤 낌새도 지금은 찾아 볼 수 없으니 말이다.
한마디로 앞에서 거론한 것에 의해 그렇게 낭만적인 것만은 아니라는 사실,
Alzheimer's Disease에서 그와 관련된 상황을 이해하기로 한다.
더 보기 참고 출처 사이트;
http://news.sciencemag.org/brain-behavior/2013/10/sleep-ultimate-brainwasher
http://www.sciencemag.org/content/342/6156/373
http://en.wikipedia.org/wiki/Beta_amyloid
https://www.fightaging.org/take-action/
http://www.eurekalert.org/pub_releases/2014-02/uops-sif022014.php
http://en.wikipedia.org/wiki/Nuclear_magnetic_resonance
[Scientists] have been studying the molecular mechanisms underpinning sleep. Now they report that the pathways of aging and sleep intersect at the circuitry of a cellular stress response pathway, and that by tinkering with those connections, it may be possible to alter sleep patterns in the aged for the better - at least in fruit flies.
Increasing age is well known to disrupt sleep patterns in all sorts of ways. Aging is associated with increasing
levels of protein unfolding, a hallmark of cellular stress called the "unfolded protein response." Protein misfolding
is also a characteristic of several age-related neurodegenerative diseases, such as Alzheimer's and Parkinson's diseases, and as it turns out, also associated with sleep deprivation. [The researchers] wanted to know if
rescuing proper protein folding behavior might counter some of the detrimental sleep patterns in elderly individuals.
They found that aged flies took longer to recover from sleep deprivation, slept less overall, and had their sleep
more frequently interrupted compared to younger control animals. However, adding a molecule that promotes proper protein folding - a molecular "chaperone" called PBA - mitigated many of those effects, effectively giving
the flies a more youthful sleep pattern. PBA (sodium 4-phenylbutyrate) is a compound currently used to treat such protein-misfolding-based diseases as Parkinson's and cystic fibrosis. Molecular analysis of sleep-deprived and PBA-treated flies suggested that PBA acts through the unfolded protein response.
The team also asked the converse question: Can protein misfolding induce altered sleep patterns in young animals. Another drug, tunicamycin, induces protein misfolding and stress, and when the team fed it to young flies, their sleep patterns shifted towards those of aged flies, with less sleep overall, more interrupted sleep at night, and longer recovery from sleep deprivation.
Link: http://www.eurekalert.org/pub_releases/2014-02/uops-sif022014.php
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